New specification of SCP Complex-LS

Undenatured Proteoglycan


Linise Ltd. and Anti-Aging Pro corporation, we changed the specification of SCP Complex-LS as follows on March 01, 2023.

Undenatured Proteoglycan Molecular weight:
(old) 900 to 1,400 kDa by HPLC
(new) 2,000 to 4,150 kDa by HPLC with Multi Angle Light Scattering

Download: The latest specification revised on March 01, 2023

The undenatured proteoglycan of salmon cartilage has the crosslinked structure of 2-3 aggrecan of proteoglycan. The crosslinked structure is cut in GPC column for HPLC analysis on the HPLC analysis process. So we could not show the real molecular weight of undenatured proteoglycan until now. On the other hand, we could show the real molecular weight (2,000 to 4,150 kDa) by HPLC with Multi Angle Light Scattering this time. With this new knowledge, we changed the specification.

Undenatured Collagens


Also we have discovered another new knowledge in relation to undenatured collagen of salmon cartilage. As results of research and development with Fukui Prefectural University, we succeeded in separating type II collagen and type XI collagen on the electrophoresis (right figure, in Japanese) and discovered that salmon cartilage has type XI collagen with type II collagen.

And the study of new knowledge was submitted by Professor Mizuta (Fukui Prefectural University) and be published on Fisheries Science in April, 2023. With the publishing of study, we change the specification as follows in 2024.

(now ) Undenatured type II collagen: 40.0 ％ or more by Automatic amino acid analyzer and Differential scanning calorimetry
(new) Undenatured type II & XI collagen: 40.0 ％ or more by Automatic amino acid analyzer and Polyacrylamide electrophoresis *: Type II : Type XI = about 8 : 2



We change the specification, but the essence of material is the same with the existing material. And we don’t change the manufacturing method/process and the source.

Reference
Shoshi Mizuta et al. Characterization of collagen in salmon nasal cartilage: enzymatic solubilization with fungal acid protease. Fisheries Science. 2023;89 507–513.

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